Entrepreneurs almost always have to step out of existing institutions that embody old ways of doing things to build their vision.
We started Ashoka here in India with a simple idea: that you needed social entrepreneurs to deal with problems that don't fit the business paradigm.
Organizations must shift away from repetitive-function hierarchies with rules and enforcement and walls. Instead, we must migrate rapidly to becoming a global 'team of teams' that comes together in whatever combination necessary to add the greatest value to the changes underway.
It's the combination: big idea with a good entrepreneur: there's nothing more powerful.