I went to college thinking of maybe pursuing a career in film criticism.
Given the current state of publishing, I think it helps to have a brand name on the cover of your book. Comedians are proven commodities with built-in audiences. They may not have the writing chops of a Dave Eggers, but they're salacious and funny and self-reflective.
I am a big proponent of writing a great outline. That way you can avoid hitting a roadblock. There is no worse feeling than writing yourself into a corner but if you've figured it all out in the outline then you won't have that problem.