Take risks. Ask big questions. Don't be afraid to make mistakes; if you don't make mistakes, you're not reaching far enough.
The most important question we have to deal with is a combination of population control and the control of our environment - how to utilize the world in as effective a way as we can for the future of mankind.
I think that we must find some way to get more common sense, more rationality, in our decisions and less emotion.
Why are we here? I think many people assume, wrongly, that a company exists solely to make money. Money is an important part of a company's existence, if the company is any good. But a result is not a cause. We have to go deeper and find the real reason for our being.